The fifth round also contains outings for Premier League clubs Liverpool, Chelsea, Everton, Norwich City and Bolton Wanderers.
Arsenal were on Wednesday humiliated in their UEFA Champions League last 16 first leg against AC Milan as they were hammered 4-0 at the San Siro in what was one of the English club's worst performances for several years.
The fallout from the horror show saw manager Arsene Wenger on Thursday reportedly go 'crazy' at his squad during training and players could well be fighting for their futures for the rest of the season.
A trip to Sunderland on Saturday evening is therefore far from ideal for Arsenal following Martin O'Neill's much-publicised rejuvenation at the Stadium of Light.
But Wenger's men have inflicted one of the three defeats O'Neill has suffered as Sunderland boss after Thierry Henry's late goal grabbed a 2-1 win on Wearside last weekend.
The Gunners, though, have won only two of their last seven FA Cup ties away from home.
The romance of the FA Cup will on Sunday be fully evident in Stoke's trip to League Two Crawley.
In the space of four days, Tony Pulis' side will have gone from rubbing shoulders with the European elite and Spanish heavyweights of Valencia to a tricky domestic cup tie at Broadfield Stadium.
Crawley are the lowest ranked club left in this season's FA Cup and boss Steve Evans will be aspiring towards a piece of history against last season's defeated finalists.
Stoke, though, have won their last four FA Cup matches away from home, keeping a clean sheet in three of those games, and Pulis will not expect any complacency.