Kenny Dalglish's side hold a one-goal aggregate advantage in their bid to end a six-year trophy drought after Steven Gerrard's penalty settled the first leg at the Etihad Stadium.
But Roberto Mancini's City remain confident of a return to Wembley, having won last season's FA Cup before losing in the Community Shield at the beginning of this campaign.
The Premier League leaders are expected to be in a determined mood at Anfield and, after dominating the first leg without scoring, it is expected to be a tense night in the battle to meet Cardiff in the final.
Liverpool and City drew 1-1 at Anfield earlier in the season in the Premier League in what was a gripping encounter, but Dalglish's team were heavily beaten at the Etihad in January.
For the Merseysiders, though, the Carling Cup